Spondyloarthritis (SpA) describes a group of inflammatory diseases primarily affecting the spine and joints, but which can also involve organs such as the eyes, skin, and intestines.
These conditions often emerge in people under 45, most frequently in young adults. In the United States, more than 3 million individuals are diagnosed with some form of SpA, making it more prevalent than several other well-known autoimmune disorders.
 

Types of Spondyloarthritis SpA is generally categorized into two main types, which can overlap:

  • Axial spondyloarthritis: This form mainly targets the spine and hips, causing persistent pain, stiffness, and inflammation.
  • Peripheral spondyloarthritis: This type affects joints and tendons outside the spine, such as those in the hands, feet, knees, and ankles, and leads to swelling or discomfort.

It’s not unusual for a person to show both axial and peripheral symptoms. The dominant symptoms help determine the specific diagnosis.

Axial Spondyloarthritis (axSpA) A characteristic feature of axSpA is ongoing pain and stiffness in the lower back or buttocks, often due to inflammation in the sacroiliac joints (the joints connecting the spine to the pelvis). This pain usually develops gradually, often before age 45, and persists for more than three months. Physical activity tends to ease the discomfort, while rest does not. Morning stiffness lasting at least 30 minutes is also common. Other possible symptoms include involvement of the neck, hips, shoulders, eyes (iritis), digestive tract (inflammatory bowel disease), and skin (psoriasis).

 

AxSpA is divided into two subtypes:

  • Radiographic axSpA (Ankylosing Spondylitis): X-rays reveal changes or fusion in the spine.
  • Non-radiographic axSpA: Symptoms are similar, but x-rays do not show these changes. MRI may still detect inflammation, and some people with this form later develop ankylosing spondylitis.

Peripheral Spondyloarthritis (pSpA). Peripheral SpA leads to inflammation and pain in joints and tendons outside the spine. Joints commonly affected include the hands, wrists, elbows, shoulders, knees, ankles, and feet. Symptoms may also include dactylitis (swelling of an entire finger or toe) and enthesitis (inflammation at points where tendons attach to bones). Other organs, like the eyes, gut, or skin, may also be affected.

Subtypes of Peripheral Spondyloarthritis

  • Psoriatic Arthritis (PsA): This type is marked by pain and swelling in the small joints of the hands and feet, often alongside psoriasis (scaly skin patches). It can also affect the spine or cause dactylitis.
  • Enteropathic Arthritis: Occurs in people with inflammatory bowel diseases such as Crohn’s disease or ulcerative colitis, and often comes with gastrointestinal symptoms.
  • Reactive Arthritis: Typically develops after an infection in the digestive or urinary tract. This condition can cause joint inflammation and may involve the eyes, skin, or urinary/genital systems. Usually, symptoms are short-lived but may persist or recur in some people.

Undifferentiated Spondyloarthritis: This term is used when a person’s symptoms don’t fit neatly into other SpA categories. For example, someone may have eye inflammation, heel pain, and knee swelling, but not display other classic signs.

Juvenile Spondyloarthritis (JSpA) When spondyloarthritis develops in children or adolescents, it’s termed juvenile spondyloarthritis. It can show up as either spinal (axial) or peripheral disease. Enthesitis—pain and swelling where tendons and ligaments attach to bone—is especially common in young patients.

Spondyloarthritis is a diverse set of diseases that can impact the spine, joints, and various organs. Early recognition and tailored management are essential for reducing symptoms and preventing complications. Understanding the different types of SpA helps ensure that individuals receive the care they need for improved comfort and quality of life.

 

Source:
National Institute for Health and Care Excellence (NICE). Spondyloarthritis in over 16s: diagnosis and management.
Available from: https://www.ncbi.nlm.nih.gov/books/NBK553609/

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This information is for educational purposes only and should not replace professional medical advice. Always consult with your healthcare provider for diagnosis and treatment recommendations specific to your condition.